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Impact of Gm15441 knockdown on gene expression profile of mouse liver in response to activation of PPARA by WY-14643.

ABSTRACT: Gene expression in livers of wild type adult male mice and in Gm15441 knockdown adult male mouse liver (Gm15441-LSL mice) was assayed by RNA-seq, as part of a study of liver transcriptomic changes in response to activation of PPARA by WY-14643.

ORGANISM(S): Mus musculus

PROVIDER: GSE132385 | GEO | 2020/09/14

REPOSITORIES: GEO

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Gene expression profile of mouse liver in response to activation of PPARA by WY-14643.

Project description:Gene expression in adult male mouse liver was assayed by RNA-seq, as part of a study of liver transcriptomic changes in response to activation of PPARA by WY-14643.

2020-09-14 | GSE132386 | GEO

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Impact of knockdown of the lncRNA 3930402G23Rik on gene expression profile of mouse liver in response to activation of PPARA by WY-14643.

Project description:Gene expression in livers of wild type adult male mice and in lncRNA 3930402G23Rik ("G23Rik") knockdown adult male mouse liver was assayed by RNA-seq, as part of a study of liver transcriptomic changes in response to activation of PPARA by WY-14,643, published in Molecular and Cellular Endocrinology (2022). These studies found that G23Rik-null mice were more susceptible to hepatic lipid accumulation in response to acute fasting. Histological analysis further revealed a pronounced buildup of lipid droplets and a significant increase in neutral triglycerides and lipids as indicated by enhanced oil red O staining of liver sections. Hepatic cholesterol, non-esterified fatty acid, and triglyceride levels were significantly elevated in G23Rik-null mice and associated with induction of the lipid-metabolism related gene Cd36. These findings provide evidence for a lncRNA dependent mechanism by which PPARA attenuates hepatic lipid accumulation in response to metabolic stress through lncRNA G23Rik induction.

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Gene expression profile in livers from control or Wy-14643 treated MycF/F or MycF/F,ERT2-Cre mice

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Gene expression profile of mouse liver in response to activation of PPARA by WY-14643.

Project description:Gene expression profile of mouse liver in response to activation of PPARA by WY-14643.

| PRJNA547791 | ENA

Effect of WY-14643 on Rat Primary Hepatocytes.

Project description:This study provides an evaluation of changes in gene expression associated with WY-14643 treatment of rat hepatocytes in vitro. Primary rat hepatocytes were treated for 24 and 48 hours with two doses 8 uM and 200 uM) of WY-14643 and 1% DMSO vehicle control. Five replicates of each treatment were performed. Cells were then extracted and RNA processed for microarray analysis. This series is part of a SuperSeries in which primary rat hepatocytes were treated with two doses of ten chemical compounds (and corresponding vehicle controls) for 24 and 48 hours. Each compound/vehicle treatment group was an individual study performed at different times. Each study was analyzed separately and themes common between studies were reported. Time Course/Dose Response

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Impact of Gm15441 knockdown on gene expression profile of mouse liver in response to activation of PPARA by WY-14643.

Project description:Impact of Gm15441 knockdown on gene expression profile of mouse liver in response to activation of PPARA by WY-14643.

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Impact of knockdown of the lncRNA 3930402G23Rik on gene expression profile of mouse liver in response to activation of PPARA by WY-14643.

Project description:Impact of knockdown of the lncRNA 3930402G23Rik on gene expression profile of mouse liver in response to activation of PPARA by WY-14643.

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