Transcriptomics

Dataset Information

0

Acquired resistance to targeted therapy confers cross-resistance to immunotherapy


ABSTRACT: We identify a profoundly remodelled TME in targeted therapy resistant (RTT) tumours. We provide bulk transcriptomic data of targeted therapy naive (NTT) and RTT tumours of 3 murine models. Additionally, we provide low-input sequencing of CD103+ dendritic cells and T cells from NTT and RTT Braf/Pten tumours. We identified that in RTT cell lines the MAPK pathway is reactivated and provide SLAM-seq data to determine transcriptional targets of MAPK pathway inhibition in NTT and RTT cell lines. We also provide ATAC-Seq data of NTT and RTT cell lines sorted from tumors of the Braf/Pten melanoma model.

ORGANISM(S): Mus musculus

PROVIDER: GSE132443 | GEO | 2021/06/26

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2014-02-19 | E-GEOD-50509 | biostudies-arrayexpress
2024-04-23 | PXD033921 | Pride
2024-04-23 | PXD033866 | Pride
2013-06-30 | E-GEOD-44753 | biostudies-arrayexpress
2011-10-12 | E-GEOD-32907 | biostudies-arrayexpress
2014-02-19 | GSE50509 | GEO
2024-04-23 | GSE255541 | GEO
2013-06-30 | GSE44753 | GEO
2021-04-13 | GSE126524 | GEO
2021-04-13 | GSE163085 | GEO