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An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE132558 | GEO | 2020/06/11

REPOSITORIES: GEO

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An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate.

Project description:OTX2 is a potent oncogene that promotes tumor growth in Group 3 medulloblastoma. However, the mechanisms by which OTX2 represses neural differentiation are not well characterized. Here, we perform extensive multiomic analyses to identify an OTX2 regulatory network that controls Group 3 medulloblastoma cell fate. OTX2 silencing modulates the repressive chromatin landscape, decreases levels of PRC2 complex genes and increases the expression of neurodevelopmental transcription factors including PAX3 and PAX6. Expression of PAX3 and PAX6 is significantly lower in Group 3 medulloblastoma patients and is correlated with reduced survival, yet only PAX3 inhibits self-renewal in vitro and increases survival in vivo. Single cell RNA sequencing of Group 3 medulloblastoma tumorspheres demonstrates expression of an undifferentiated progenitor program observed in primary tumors and characterized by translation/elongation factor genes. Identification of mTORC1 signaling as a downstream effector of OTX2-PAX3 reveals roles for protein synthesis pathways in regulating Group 3 medulloblastoma pathogenesis.

| S-EPMC7371715 | biostudies-literature

An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate [scRNA-seq]

Project description:scRNA-seq was performed to evaluate the OTX2-PAX3-mTOR signalling axis at the single cell level in heterogeneous Group 3 MB tumorspheres

2020-06-11 | GSE137758 | GEO

An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate [ChIP-seq]

Project description:We evaluated changes in active and repressive histone modifications following the silencing of OTX2 in Group 3 medulloblastoma tumorspheres

2020-06-11 | GSE132269 | GEO

An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate [RNA-seq]

Project description:RNA-seq was carried out to evaluate the molecular mechanisms that contribute to the distinguishing effects of PAX3 and PAX6 GOF on Group 3 MB cells

2020-06-11 | GSE132506 | GEO

An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate

Project description:An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate

| PRJNA548355 | ENA

An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate [ChIP-seq]

Project description:An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate [ChIP-seq]

| PRJNA547350 | ENA

An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate [scRNA-seq]

Project description:An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate [scRNA-seq]

| PRJNA566451 | ENA

An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate [RNA-seq]

Project description:An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate [RNA-seq]

| PRJNA548193 | ENA

Characterization of a novel OTX2-driven self-renewal program in Group 3 and Group 4 medulloblastoma

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-01-01 | GSE98384 | GEO

OTX2 activity at distal regulatory elements shapes the chromatin landscape of Group 3 medulloblastoma

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-02-21 | GSE92585 | GEO

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