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MRNA-Seq of BC-3 IRF4 KO, BATF KO, and vIRF3 KD

ABSTRACT: The Kaposi's sarcoma-associated herpesviruses causes several cancers including Kaposi's sarcoma and primary effusion lymphoma (PEL). Our work reveals that the cellular transcription factors interferon regulatory factor 4 (IRF4) and basic leucine zipper ATF-like transcription factor (BATF), as well as the viral interferon regulatory factor 3 (vIRF3) are critical oncogenic dependencies specific to PEL cell lines. To understand the functions of these transcription factors, we performed mRNA-Seq on the PEL BC-3 cell lines that have been targeted for CRISPR/Cas9 IRF4 KO, BATF KO and MDM4 KO (as unrelated negative control) and CRISPRi-mediated vIRF3 KD. Our results reveal that these oncogenic factors may cooperate to regulate the expression of the same mRNAs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE132707 | GEO | 2020/08/13

REPOSITORIES: GEO

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ChIP-Seq of IRF4, BATF, and vIRF3 in BC-3 cells

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2012-09-18 | E-GEOD-39756 | biostudies-arrayexpress

mRNA-Seq of BC-3 IRF4 KO, BATF KO, and vIRF3 KD

Project description:mRNA-Seq of BC-3 IRF4 KO, BATF KO, and vIRF3 KD

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2012-05-20 | E-GEOD-37355 | biostudies-arrayexpress

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