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Defining heterogeneity and biological signature in human effector memory CD8+ T cells expressing different levels of IL-7 receptor alpha by high-dimensional analysis

ABSTRACT: FACS-purified human effector memory (EM) CD8+ T cells were analyzed for single cell gene expression profile using single cell RNA-seq. The relationship of IL-7 receptor alpha expression with other molecules was determined at the single cell level. The results showed heterogeneity in human EM CD8+ T cells as defined by IL-7Ra expression that has distinct but organized relationships with a set of molecules, including effector molecules, chemokine receptors, and transcription factors.

ORGANISM(S): Homo sapiens

PROVIDER: GSE133167 | GEO | 2019/12/31

REPOSITORIES: GEO

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IL-6R identifies early differentiated human effector memory CD8+ T cells that potently expand and produce IL-2 and IL-13

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