Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effects of transcription on genome - nuclear lamina interactions

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE133275 | GEO | 2019/06/28

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Genome-nuclear lamina interactions regulate progenitor cell lineage restriction during cardiogenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-10-12 | GSE97878 | GEO

Genome-wide maps of nuclear lamina interactions in single human cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-09-24 | GSE69423 | GEO

Massive reshaping of genome - nuclear lamina interactions during oncogene induced senescence

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-08-17 | GSE76605 | GEO

Genome-nuclear lamina interactions regulate progenitor cell behavior during cardiac development

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-10-10 | GSE64149 | GEO

A lamina-associated domain border governs nuclear lamina interactions, transcription and recombination of the Tcrb locus.

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-10-22 | GSE116954 | GEO

Stochastic genome - nuclear lamina contacts are linked to histone H3K9 dimethylation

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-01-31 | E-GEOD-40112 | biostudies-arrayexpress

Decoding the determinants of genome-nuclear lamina interactions by a random scrambling approach

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-12-19 | GSE250307 | GEO

The insulator protein SU(HW) modulates nuclear lamina interactions of the Drosophila genome

Project description:This SuperSeries is composed of the SubSeries listed below.

2011-02-12 | GSE20313 | GEO

Local rewiring of genome-nuclear lamina interactions by transcription.

Project description:Transcriptionally inactive genes are often positioned at the nuclear lamina (NL), as part of large lamina-associated domains (LADs). Activation of such genes is often accompanied by repositioning toward the nuclear interior. How this process works and how it impacts flanking chromosomal regions are poorly understood. We addressed these questions by systematic activation or inactivation of individual genes, followed by detailed genome-wide analysis of NL interactions, replication timing, and transcription patterns. Gene activation inside LADs typically causes NL detachment of the entire transcription unit, but rarely more than 50-100 kb of flanking DNA, even when multiple neighboring genes are activated. The degree of detachment depends on the expression level and the length of the activated gene. Loss of NL interactions coincides with a switch from late to early replication timing, but the latter can involve longer stretches of DNA. Inactivation of active genes can lead to increased NL contacts. These extensive datasets are a resource for the analysis of LAD rewiring by transcription and reveal a remarkable flexibility of interphase chromosomes.

| S-EPMC7073462 | biostudies-literature

Stochastic genome - nuclear lamina contacts are linked to histone H3K9 dimethylation

Project description:This SuperSeries is composed of the SubSeries listed below.

2013-01-31 | GSE40112 | GEO