Transcriptomics

Dataset Information

0

A Congenital Anemia Dissociates the Pleiotropic Functions of Master Transcription Factor GATA1 [Patient_RNAseq]


ABSTRACT: Master regulators, such as the hematopoietic transcription factor GATA1, have numerous roles in lineage commitment and differentiation. While human GATA1 mutations result in several blood diseases, all characterized mutations act relatively early to impair hematopoietic differentiation. Here, we describe a distinct form of hemolytic anemia involving impaired terminal erythropoiesis with a reduced lifespan of circulating red blood cells. We show that this unique blood disorder results from mutations in a poorly characterized and intrinsically disordered C-terminal region of GATA1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE133414 | GEO | 2021/12/31

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-12-31 | GSE133409 | GEO
2021-12-31 | GSE133404 | GEO
2021-12-31 | GSE133403 | GEO
2021-12-31 | GSE133415 | GEO
2021-12-31 | GSE155254 | GEO
2021-12-31 | GSE155253 | GEO
2021-12-31 | GSE155255 | GEO
2020-04-08 | PXD017657 | Pride
| PRJNA551420 | ENA
2021-12-31 | GSE133417 | GEO