Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Circular RNA expression profile in the spinal cord of morphine tolerated rats and screen of putative key circRNAs

ABSTRACT: Microarray analysis for circRNA expression in the spinal cord was conducted and compared between 4 morphine tolerated rats and 4 normal rats

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE133602 | GEO | 2019/07/02

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Epitranscriptomic map of N6-methyladenosine circular RNAs in the spinal cord of morphine-tolerant rats

Project description:Morphine tolerance is a tricky problem, the mechanism of it is still unclear. Circular RNAs (CircRNAs) play important roles in biological process of central nervous system. N6-methyladenosine (m6A) as a key post-transcriptional modification of RNA can regulate the metabolism and functions of circRNAs. Here we conducted this research to explore the patterns of m6A-methylation of circRNAs in the spinal cords of 4 morphine tolerated rats and 4 normal rats.

2022-04-05 | GSE199892 | GEO

Circular RNA expression profile in the spinal cord of morphine tolerated rats and screen of putative key circRNAs

Project description:Circular RNA expression profile in the spinal cord of morphine tolerated rats and screen of putative key circRNAs

| PRJNA552027 | ENA

Circular RNA expression profile in the spinal cord of morphine tolerated rats and screen of putative key circRNAs.

Project description:Morphine tolerance developed after repeated or continuous morphine treatment is a global health concern hindering the control of chronic pain. In our previous research, we have reported that the expression of lncRNAs and microRNAs have been greatly modified in the spinal cord of morphine tolerated rats, and the modulating role of miR-873a-5p, miR-219-5p and miR-365 have already been confirmed. However, whether circular RNAs, another essential kind of non-coding RNA, are involved in the pathogenesis of morphine tolerance is still beyond our knowledge. In this study, we conducted microarray analysis for circRNA profile and found a large number of circRNAs changed greatly in the spinal cord by morphine treatment. Among them, we selected nine circRNAs for validation, and seven circRNAs are confirmed. Gene Ontology/Kyoto Encyclopedia of Genes and Genomes (GO/KEGG) analysis were used for functional annotation. Besides, we confirmed the modified expression of seven circRNAs after validation by real-time PCR, selected 3 most prominently modulated ones among them and predicted their downstream miRNA-mRNA network and analyzed their putative function via circRNA-miRNA-mRNA pathway. Finally, we enrolled the differentially expressed mRNAs derived from the identical spinal cord, these validated circRNAs and their putative miRNA targets for ceRNA analysis and screened a promising circRNA-miRNA-mRNA pathway in the development of morphine tolerance. This study, for the first time, provided valuable information on circRNA profile and gave clues for further study on the circRNA mechanism of morphine tolerance.

| S-EPMC6751888 | biostudies-literature

Identifiation of lncRNA expression profiles and ceRNA analysis in the spinal cord of morphine tolerance rats

Project description:The mechanism of morphine tolerance remains unclear, and lncRNA have been promising molecule in many pathophysiological processes. However, the role of lncRNA on morphine tolerance hasn’t been explored yet. So we explore this issue, and our results indicated that the expression profiles of lncRNAs have changed in morphine tolerance rats as compared with normal rats, and among those, some differentially expressed lncRNAs might be new therapeutic targets for morphine tolerance.

2018-04-05 | GSE110115 | GEO

Global circulating miRNA screen after morphine delivery

Project description:Opioid use is detrimental to bone health, causing both indirect and direct effects on bone turnover. The aim of the study was to develop a mouse model to evaluate the impact of sustained morphine exposure on bone turnover of both male and female mice and to identify candidate miRNA-mediated regulatory mechanisms that could affect bone.

2022-02-23 | GSE197198 | GEO

Epitranscriptomic map of N6-methyladenosine circular RNAs in the spinal cord of morphine-tolerant rats

Project description:Epitranscriptomic map of N6-methyladenosine circular RNAs in the spinal cord of morphine-tolerant rats

| PRJNA821901 | ENA

Effects of morphine exposure on the transcriptome of the dorsalmedial prefrontal cortex (dmPFC) in rats

Project description:We investigated changes in gene transcription induced by subcutanuous morphine injection in adult male and female rats' dmPFC.

2023-06-06 | GSE233922 | GEO

Global circulating miRNA screen after morphine delivery

Project description:Global circulating miRNA screen after morphine delivery

| PRJNA809352 | ENA

Transcriptomics in the nucleus accumbens shell reveal sex- and reinforcer-specific signatures associated with morphine and sucrose craving

Project description:RNA-sequencing was performed using nucleus accumbens tissue from male and female rats following 1 or 30 days of morphine self-admininstration or sucrose self-adminnistration.

2024-05-19 | GSE174737 | GEO

Morphine PVT TRAPSeq

Project description:Using an oral self-administration paradigm, we have seen morphine increase neural activity in the Paraventricular Nucleus of the Thalamus (PVT). Morphine binds primarily to Mu Opioid Receptors (MORs), which are highly expressed in the PVT. Translating Ribosome Affinity Purification (TRAP)-Sequencing was conducted on PVT neurons that express MORs

2022-10-04 | GSE214560 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data