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Single-cell connectomic analysis of adult mammalian lungs

ABSTRACT: Single-cell RNA sequencing (scRNAseq) has made it possible to analyze complex organs such as the lung with unprecedented resolution. We have leveraged these techniques to identify conserved patterns of cell-cell cross-talk in adult mammalian lungs, analyzing mouse, rat, pig and human pulmonary tissues. Following clustering and histological registration, we mapped putative ligand-receptor interactions within and between cell types and assessed the significance of these interactions. Our findings demonstrate specific, stereotyped functional roles for each cell type in the distal lung which emerge as top candidates for the regulation of tissue phenotype.

ORGANISM(S): Mus musculus Rattus norvegicus Homo sapiens Sus scrofa

PROVIDER: GSE133747 | GEO | 2019/12/04

REPOSITORIES: GEO

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