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Chromatin binding protein PHF6 regulates activity-dependent transcription networks to promote hunger response [ChIP-Seq]

ABSTRACT: We revealed that PHF6 was bound to the promoters of a subset of neuronal immediate-early genes (IEGs), and this chromatin binding was dynamically regulated by hunger state.

ORGANISM(S): Mus musculus

PROVIDER: GSE133901 | GEO | 2020/03/16

REPOSITORIES: GEO

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Chromatin binding protein PHF6 regulates activity-dependent transcription networks to promote hunger response [RNA-Seq]

Project description:We revealed that PHF6 bound to the promoters of a subset of neuronal immediate-early genes (IEGs) and regulate their expression levels. hunger state.

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Chromatin binding protein PHF6 regulates activity-dependent transcription networks to promote hunger response

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Chromatin binding protein PHF6 regulates activity-dependent transcription networks to promote hunger response

Project description:This SuperSeries is composed of the SubSeries listed below.

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PHF6 OCCUPANCYIN HUMAN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Project description:Here we identify the genome-wide occupancy of PHF6 in T-ALL cells. Human T-ALL cells were cross-linked with formaldehyde for 20 min. DNA was enriched by chromatin immunoprecipitation (ChIP) and analyzed by Solexa sequencing. A sample of whole cell extract (WCE) was sequenced and used as the background to determine enrichment. ChIP was performed using an antibody against total PHF6 (Bethyl A301-451A). This represents the ChIP-seq portion of this dataset.

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AgRP neuron epigenomes across hunger states reveal that IRF3 mediates leptin's effects

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