Transcriptomics

Dataset Information

0

Blast preconditioning protects retinal ganglion cells and reveals targets for prevention of neurodegeneration following blast-mediated TBI


ABSTRACT: Purpose: The purpose of this study was to examine the effect blast preconditioning on the structure and function of retinal ganglion cells (RGC), and to identify molecular pathways that contribute to RGC loss. Methods: To examine the effect of blast-preconditioning three groups of mice were analyzed, including those 1) subjected to sham injury followed by one single 20 PSI injury one week later, 2) mice exposed to two low intensity preconditioning blast exposures separated by one week (5 PSI, 5 PSI) and 3) mice exposed to a preconditioning injury (5 PSI) followed by a single 20 PSI blast exposure one week later. RNAseq analysis was used to identify transcriptional changes between groups. Conclusions: Preconditioning protects RGC from blast injury. Protective effects appear to involve changes in kynurenine-3-monooxygenase activity, whose inhibition is also protective.

ORGANISM(S): Mus musculus

PROVIDER: GSE133940 | GEO | 2019/09/24

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-08-14 | GSE274793 | GEO
2019-11-15 | GSE89866 | GEO
2008-06-13 | E-GEOD-4753 | biostudies-arrayexpress
2019-12-31 | E-MTAB-7982 | biostudies-arrayexpress
2006-05-02 | GSE4753 | GEO
2013-03-18 | E-GEOD-44625 | biostudies-arrayexpress
2016-08-05 | GSE71846 | GEO
2023-09-04 | GSE230253 | GEO
2022-06-28 | GSE207078 | GEO
2018-11-12 | GSE106993 | GEO