Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comprehensive analysis of the complexity and heterogeneity of the lncRNAs transcriptome in multiple myeloma

ABSTRACT: RNA-seq analysis comparing the transcriptional landscape of LINC-SMILO silenced cells versus control cells in KMS-11 multiple myeloma cell line.

ORGANISM(S): Homo sapiens

PROVIDER: GSE134057 | GEO | 2021/05/12

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Comprehensive analysis of the complexity and heterogeneity of the lncRNAs transcriptome in multiple myeloma

Project description:ssRNA-seq analysis of the transcriptional landscape of 38 multiple myeloma patients

2020-08-05 | GSE151063 | GEO

Widespread chromatin activation underlies pathogenic mechanisms in multiple myeloma

Project description:RNA-seq analysis comparing the transcriptional landscape of PRDM5 silenced vs mock KMS-11 multiple myeloma cell line

2019-11-16 | GSE122638 | GEO

Comprehensive analysis of the complexity and heterogeneity of the lncRNAs transcriptome in multiple myeloma

Project description:Comprehensive analysis of the complexity and heterogeneity of the lncRNAs transcriptome in multiple myeloma

| PRJNA553573 | ENA

Comprehensive analysis of the complexity and heterogeneity of the lncRNAs transcriptome in multiple myeloma

Project description:Comprehensive analysis of the complexity and heterogeneity of the lncRNAs transcriptome in multiple myeloma

| PRJNA634534 | ENA

Gene expression of myeloma cell lines under hypoxia

Project description:By using myeloma cell lines (RPMI8226, KMS-11, KMS-12BM, and MM.1S), we conducted whole genome gene screening against the cells that were subjected by chronic hypoxia condition.

2016-04-12 | GSE80140 | GEO

miRNA expression of myeloma cell lines under hypoxia

Project description:By using world wildly used myeloma cell lines (RPMI8226, KMS-11, KMS-12BM, and MM.1S), we conducted whole miRNA screening against the cells that were subjected by chronic hypoxia condition.

2016-04-29 | GSE80769 | GEO

Transcription profiling of human multiple myeloma cell lines treated with EZH2 inhibitor E7438 and DMSO controls

Project description:We used a total of 10 human multiple myeloma cell lines for the study (KMS-20, KMS-28BM, MOLP-8, RPMI-8226, U-266, KMS-11, KMS-12-PE, KMS-34, LP-1 and NCI-H929). Cells (2 x 105 per well) were seeded into six-well culture plates in the appropriate culture media 24 h before treatment. Five replicate wells were then exposed to 2 uM of E7438 or control DMSO for 3 days. Cells were collected and RNA was extracted using RNeasy kit (Qiagen) according to the manufacturer’s instructions. For each sample, 250ng of total RNA was amplified using the Affymetrix GeneChip WT PLUS Reagent Kit according to the protocol described in User Manual Target Preparation for GeneChip Whole Transcript (WT) Expression Arrays (P/N 703174 Rev. 2). An Affymetrix Human Gene 2.1 ST 96-array plate was hybridized with 3µg of fragmented and labeled ss cDNA, washed, stained, and scanned according to the protocol described in User Manual GeneTitan®Instrument User Guide for Expression Arrays Plates (P/N 702933 Rev.1) and Affymetrix® GeneChip® Command Console™ User’s Guide (P/N 702569 Rev.9) using the Affymetrix GeneTitan instrument.

2016-01-11 | E-MTAB-3540 | biostudies-arrayexpress

Gene expression of myeloma cell lines with miR-7 transduction

Project description:Gene expression of myeloma cell lines (MM.1S and KMS-11) transiently transduced with miR-7 and cultured for 48 h.

2024-01-31 | GSE253489 | GEO

The gene expression profiles of hypoxia-resistant (HR) human multiple myeloma cell lines

Project description:In multiple myeloma (MM), abnormal plasma cells interact with bone marrow (BM) stromal cells and vascular cells among others. A part of the BM milieu is considered highly hypoxic, and myeloma cells in situ may be influenced by circumstances other than normoxia in vitro. Hence, we attempted to confirm the role of hypoxic MM-derived exosomes in the BM milieu. We established a novel hypoxia-resistant cell line, RPMI8226-HR derived from RPMI8226 cells, KMS-11-HR derived from KMS-11, U266-HR derived from U266, and IM-9-HR derived from IM-9 cultured for >4 months under hypoxia (1% O2), as a model of MM cells localizing in an extensively hypoxic milieu. We used RPMI8226 cells and RPMI8226-HR cells, as donor cells, and HUVECs as recipient cells. Exosomes derived from RPMI8226 cells (normoxia or hypoxia) and exosomes derived from RPMI8226-HR cells (hypoxia-resistant, HR sub-line) were used for validation of angiogeneic activity, such as tube formation assay. Exosomes derived from the RPMI8226-HR cells significantly increased tube formation of HUVECs than those from RPMI8226 cells.

2018-02-06 | GSE110113 | GEO

miRNA expression of myeloma cell lines cultured with HDAC inhibitors panobinostat and vorinostat

Project description:miRNA expression of myeloma cell lines (MM.1S and KMS-11) cultured with HDAC inhibitors (10 nM panobinostat and 1 uM vorinostat) for 48h.

2024-01-31 | GSE253488 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data