Transcriptomics

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Influence of hyperthyroid conditions on gene expression in rat tibialis anterior


ABSTRACT: Extraocular muscles (EOMs) are a highly specialized type of tissue with a wide range of unique properties, including characteristic innervation, development, and structural proteins. Even though EOMs are frequently and prominently involved in thyroid-associated diseases, little is known about the immediate effects of thyroid hormone on these muscles. In order to create a comprehensive profile of changes in gene expression levels in EOMs induced by thyroid hormone, hyperthyroid conditions were simulated by treating adult Sprague-Dawley rats with intraperitoneal injections of 25 μg T3 per 100 g body weight over the course of six weeks; subsequently, microarray analysis was used to determine changes in mRNA levels in EOMs from T3-treated animals relative to untreated controls. RNA isolated from tibialis anterior muscles of the same animals was used as a reference fast-twitch muscle.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE13413 | GEO | 2009/03/06

SECONDARY ACCESSION(S): PRJNA113983

REPOSITORIES: GEO

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