Genomics

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Array-based comparative genomic hybridization study of human embryonic stem cell lines


ABSTRACT: G-banding of human embryonic stem cells (hESC) has proved their predisposition to aneuploidy of chromosomes 12, 17 and X. Now, using array-based comparative genomic hybridization, we find that hESC also accumulate other recurrent chromosomal abnormalities, such as duplications of stemness genes, submicroscopic instability of 20q11.21 and the appearance of a derivative chromosome 18. Keywords: comparative genomic hybridization, genomic integrity of human embryonic stem cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE13422 | GEO | 2008/11/04

SECONDARY ACCESSION(S): PRJNA110075

REPOSITORIES: GEO

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