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Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscle

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE134313 | GEO | 2020/04/02

REPOSITORIES: GEO

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Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles.

Project description:Somatic stem cells expand massively during tissue regeneration, which might require control of cell fitness, allowing elimination of non-competitive, potentially harmful cells. How or if such cells are removed to restore organ function is not fully understood. Here, we show that a substantial fraction of muscle stem cells (MuSCs) undergo necroptosis because of epigenetic rewiring during chronic skeletal muscle regeneration, which is required for efficient regeneration of dystrophic muscles. Inhibition of necroptosis strongly enhances suppression of MuSC expansion in a non-cell-autonomous manner. Prevention of necroptosis in MuSCs of healthy muscles is mediated by the chromatin remodeler CHD4, which directly represses the necroptotic effector Ripk3, while CHD4-dependent Ripk3 repression is dramatically attenuated in dystrophic muscles. Loss of Ripk3 repression by inactivation of Chd4 causes massive necroptosis of MuSCs, abolishing regeneration. Our study demonstrates how programmed cell death in MuSCs is tightly controlled to achieve optimal tissue regeneration.

| S-EPMC7242912 | biostudies-literature

Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscle [ATAC-Seq]

Project description:We performed a thorough study to analyze the epigenetic suppression of genes enabling programmed cell death as part of the muscle regeneration program. ATACseq analysis here serves as a method to compare the chromatin state and accessibilty of MuSCs in their quiescent state.

2020-04-02 | GSE117092 | GEO

Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscle [RNA-seq 3]

Project description:We performed a thorough study to analyze the epigenetic regulation of genes enabling programmed cell death as part of the chronic muscle regeneration.

2020-04-02 | GSE134132 | GEO

Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscle [RNA-seq 2]

Project description:We performed a thorough study to analyze the epigenetic suppression of genes enabling programmed cell death as part of the muscle regeneration program.

2020-04-02 | GSE134131 | GEO

Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscle [RNA-seq 1]

Project description:We performed a thorough study to analyze the epigenetic suppression of genes enabling programmed cell death as part of the muscle regeneration program. RNAseq analysis here serves as a method to compare the differentially deregulated genes upon knockdown of Chd4 in MuSCs using Adenoviral CRE recombination.

2020-04-02 | GSE117008 | GEO

Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscle

Project description:Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscle

| PRJNA554685 | ENA

Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscle [ATAC-Seq]

Project description:Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscle [ATAC-Seq]

| PRJNA481035 | ENA

Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscle [RNA-seq 1]

Project description:Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscle [RNA-seq 1]

| PRJNA480838 | ENA

Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscle [RNA-seq 3]

Project description:Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscle [RNA-seq 3]

| PRJNA554013 | ENA

Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscle [RNA-seq 2]

Project description:Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscle [RNA-seq 2]

| PRJNA554012 | ENA

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