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Irradiation of healthy brain alters expression of genes involved in cell motility and invasiveness of glioblastoma

ABSTRACT: Traumatic brain injury is known to cause proliferation and migration of astrocytic and neuronal cells. To find out whether irradiation may influence migration of intracranial tumors, we performed expression profiling of orthotopically implanted glioblastomas following irradiation to the contralateral (non-diseased) hemisphere. Microarrays were used to identify differentially expressed genes associated with glioblastoma-malignancy in distinct tumor compartments following irradiation of brain tissue of contralateral (non-diseased) hemisphere. Differentially expressed genes were the object to functional network analysis with Ingenuity pathway analysis software

ORGANISM(S): Homo sapiens

PROVIDER: GSE134711 | GEO | 2020/10/14

REPOSITORIES: GEO

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