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Proteinase-Activated Receptor 4 (PAR4) mediates cell membrane blebbing in a Gaq/11, Gai independent, RhoA and ß-arrestin-dependent manner.

ABSTRACT: To gain a comprehensive understanding of *-arrestin mediated signaling downstream of PAR4 and to guide future studies, we undertook RNAseq analysis of PAR4 activated genes in control cells and in cells lacking *-arrestin-1/-2. The results of this analysis revealed PAR4 regulation of genes involved in processes including blood coagulation and circulation, cell-cell adhesion, sensory perception and neuron-neuron synaptic transmission, terms that relates back to known function of PAR4.

ORGANISM(S): Homo sapiens

PROVIDER: GSE134713 | GEO | 2019/11/01

REPOSITORIES: GEO

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Lung transcriptomes of wild type, β-arrestin 1 -/-, and β-arrestin 2 -/- mice exposed to normoxia or chronic hypoxia

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