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Hepatic microRNA signatures in experimental nonalcoholic steatohepatitis

ABSTRACT: Two-month-old C57BL/6J male mice were placed on chow diet or a diet enriched in high fat, cholesterol, and fructose (Research diet D09100301: 40 kcal% fat, 2% cholesterol, 20 kcal% fructose, HFCF diet) for 1 or 3 months. Liver RNA was isolated and submitted for small RNA sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE135106 | GEO | 2020/03/30

REPOSITORIES: GEO

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RNA sequencing analysis of hepatic transcriptome profiles in experimental nonalcoholic steatohepatitis

Project description:Two-month-old C57BL/6J male mice were placed on either chow diet or a diet enriched in high fat, cholesterol, and fructose (Research diet D09100301: 40 kcal% fat, 2% cholesterol, 20 kcal% fructose, HFCF diet) for 1 or 3 months. RNA-seq was used to analyze hepatic gene expression from mice on 1-month chow diet, 1-month HFCF diet, 3-month chow diet, and 3-month HFCF.

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