Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Responses to DNA vaccine against H5 virus in spleens of Rosa 1 chickens

ABSTRACT: Laying hens Rosa 1 were immunized with two doses of DNA vaccine, based on the hemagglutinin (HA) DNA from H5N1 virus, in comparison to the control group, which was administered an empty vector (pCI). Additional groups of Rosa 1 hens were treated with one dose of above described vaccine or empty vector. Gene expression changes in the spleens of chickens were investigated at 7 day post last vaccination dose.

ORGANISM(S): Gallus gallus

PROVIDER: GSE135670 | GEO | 2020/02/29

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Responses to DNA vaccine against H5 virus in White Leghorn SPF chickens.

Project description:White Leghorn SPF chickens were immunized with two doses of DNA vaccine, based on the hemagglutinin (HA) DNA from H5N1 virus, in comparison to the control group, which was administered an empty vector (pCI). Gene expression changes in the spleens of chickens were investigated at 7 day post booster dose.

2020-02-29 | GSE135669 | GEO

Spleen transcriptional profiling of Mus musculus BALB/c strain after DNA vaccination against influenza H5N1

Project description:Hemagglutinin of the influenza virus is the main external glycoprotein. This very immunogenic protein is the target of the most anti-influenza vaccines. DNA vaccines are new alternative to conventional inactivated ones. Four DNA vaccines were tested. Each tested variant was based on the pCI vector with nucleotide sequence encoding hemagglutinin from A/swan/Poland/305-135V08/2006 (H5N1, clade 2.2). In K3/pCI, GK/pCI and HAneo/pCI the different optimization algorithms of hemagglutinin encoding sequence without amino acids change were tested. In 3NF/pCI the NFkappaB binding sites flanking the expression cassette were included in order to improve the nuclear transfer. Comparative transcriptome analysis of mice vaccinated the following vaccine HAneo/pCI,K3/pCI, GK/pCI or 3NF/pCI versus empty vector demonstrated minor changes in genes expression pattern. Most genes were expressed on the similar level in the vaccinated individuals and in the control mice. Small number of genes in particular variants showed the expression different than in the control mice. In general, the identified genes with the changed expression included some genes involved in metabolic processes and none of them seem to induce any undesirable pathways nor disease.

2017-09-14 | GSE101747 | GEO

Transcriptional response to a prime/boost vaccination of chickens with three vaccine variants based on HA DNA and Pichia-produced HA protein

Project description:Broilers were immunized with three variants of subunit vaccines, based on the hemagglutinin (HA) DNA and Pichia-produced HA protein from H5N1 virus, in comparison to the control group, which was administered an empty vector (pCI). Gene expression changes in the spleens of chickens were investigated at 7 day post booster dose.

2018-07-12 | GSE102972 | GEO

Responses to DNA vaccine against H5 virus in spleens of Rosa 1 chickens

Project description:Responses to DNA vaccine against H5 virus in spleens of Rosa 1 chickens

| PRJNA559614 | ENA

Rosa Damascena Stem Cell-derived Exosome

Project description:Analysis of Rosa Damascena Stem Cell-derived Exosome

2023-08-21 | PXD043169 | Pride

Effect of Rosa roxburghii fruit extracts to gene expression of mesenchymal stem cells

Project description:Here we found Rosa roxburghii fruit extracts effectively increase TERT expression and telomerase activity in cultured human mesenchymal stem cells. Both Rosa roxburghii fruit extracts by freeze drying and spray drying methods increase the activity of telomerase. Rosa roxburghii fruit freeze drying extracts is able to reduce reactive oxygen species levels, enhance SOD activity and resistance to oxidative stress, and reduce DNA damage caused by oxidative stress or radiation. Rosa roxburghii fruit extracts promoted cell proliferation, improved senescent cell morphology, delayed replicative cellular senescence, attenuated cell cycle supressors and alleviated the senescence-associated secretory phenotype. Transcriptome and metabolic profilings found that Rosa roxburghii fruit extract promote cell proliferation and DNA repair pathways, decreased triglycerides as well. Overall, we provided a theoretical basis for the application of Rosa roxburghii fruit as an anti-aging natural product.

2024-04-01 | GSE261987 | GEO

Rosa chinensis x Rosa wichuriana

Project description:Rosa chinensis x Rosa wichuriana Raw sequence reads

| PRJNA516159 | ENA

Rosa chinensis breed:Rosa chinensis

Project description:Rosa chinensis breed:Rosa chinensis Raw sequence reads

| PRJNA905852 | ENA

Deep sequencing and analysis of small RNAs from the flowers of four Rosa

Project description:High-throughput sequencing was employed to identify conserved and variable microRNAs among 4 Rosa floral sRNA profiles generated from Rosa (Vital, Marrussia, Simpas, Haedang)

2014-07-11 | E-GEOD-39882 | biostudies-arrayexpress

Rosa multiflora

Project description:Rosa multiflora

| PRJNA72313 | ENA