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Lipotoxic Injury Differentially Regulates Brain Microvascular Gene Expression in Male Mice

ABSTRACT: Hyperlipidemia is a risk factor for vascular disease and dementia, and chronic consumption of a Western Diet (WD) correlates with cognitive impairment. However, the molecular mechanisms are poorly understood. This pilot study used microarrays to investigate the nutrigenomic pathways by which the WD and hyperlipidemia generated in the low-density lipoprotein receptor deficient (LDL-R -/-) male mouse regulate gene expression in the brain hippocampus microvessels. Lipotoxic injury resulted in complex and multilevel molecular regulation of the hippocampal microvasculature involving transcriptional and post transcriptional regulation and may provide a molecular understanding for hyperlipidemia-associated dementia risk.

ORGANISM(S): Mus musculus

PROVIDER: GSE135734 | GEO | 2021/09/30

REPOSITORIES: GEO

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