Transcriptomics

Dataset Information

0

RiboTag analysis of Gfi1Cre/Cre and Gfi1Cre/+ cochlear and vestibular hair cells


ABSTRACT: In order to identify the transcriptional cascade downstream of the GFI1 repressor in inner ear hair cells, we performed a RiboTag-based expression analysis of Gfi1cre/cre mutant hair cells compared to their heterozygous controls. Through this analysis, we identified a significant downregulation of genes involved in normal hair cell development and function within the mutant hair cells, suggesting that in the absence of GFI1, the hair cells undergo a maturation arrest. Furthermore, the Gfi1 deficient hair cells displayed a significant upregulation of genes involved in neurodifferentiation and neuronal function.

ORGANISM(S): Mus musculus

PROVIDER: GSE135760 | GEO | 2020/08/01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA559929 | ENA
2018-11-28 | GSE116702 | GEO
2018-11-28 | GSE116703 | GEO
2017-03-09 | GSE85519 | GEO
2013-04-06 | E-GEOD-45799 | biostudies-arrayexpress
| PRJNA479956 | ENA
2022-03-01 | GSE153882 | GEO
2014-08-12 | E-GEOD-56866 | biostudies-arrayexpress
| PRJNA560879 | ENA
2020-09-14 | GSE130495 | GEO