EGR1 is a gatekeeper of inflammatory enhancers in human macrophages
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ABSTRACT: We investigated the function of EGR1 in macrophage differentiation and activation. We generated EGR1 CHIP-seq and CUT-and-RUN data during GM-CSF induced macrophage differentiation, paired with ATAC-seq. We performed RNA-seq and CHIP-seq for H3K27ac in EGR1-depleted differentiated macrophages. Finally we generated RNA-seq data in activated macrophages with EGR1 overexpression.
ORGANISM(S): Homo sapiens
PROVIDER: GSE136216 | GEO | 2020/01/01
REPOSITORIES: GEO
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