Transcriptomics

Dataset Information

0

Fluidigm single-cell RNA-seq analysis for gene signatures associated with T-cell persistence


ABSTRACT: A patient (4095) with metastatic colorectal cancer was treated with polyclonal tumor infiltrating lymphocytes (TILs) targeting the KRAS(G12D) hotspot mutation. Three dominant clonotypes specifically recognizing KRAS(G12D) epitopes were identified, but we found that only two clonotypes persisted 40 days after TIL treatment. Because of these findings, in this study, we performed single-cell RNA-seq analysis for the TILs isolated from this patient. This single-cell dataset is generated using a Fluidigm C1 system, followed by a Illumina HiSeq2500 sequencer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE136610 | GEO | 2020/08/28

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2019-09-10 | GSE136394 | GEO
2023-12-29 | E-MTAB-12910 | biostudies-arrayexpress
2023-08-01 | GSE229860 | GEO
2023-08-01 | GSE229858 | GEO
2024-09-13 | GSE261023 | GEO
2023-08-01 | GSE234352 | GEO
2020-06-03 | GSE145328 | GEO
2021-07-01 | E-MTAB-10681 | biostudies-arrayexpress
2022-08-30 | E-MTAB-11122 | biostudies-arrayexpress
2016-04-19 | PXD003223 | Pride