Genomics

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Single-nucleus chromatin accessibility maps of IDH mutant gliomas point to non-coding RNAs as a major influence on heterogeneity


ABSTRACT: We generated chromatin accessibility maps from 5 tumors, 336 individual nuclei, using the Fluidigm HT IFC microfluidics platform (snATAC-Seq). We were able to identify variable promoter accessibility of non-coding RNAs in LGGs. Our results point to increased CYTOR promoter accessibility in IDH-intact samples. We obtained two distinct clusters, primarily driven by histology, with a more constrained IDH-codel/oligodendroglioma cluster.

ORGANISM(S): Homo sapiens

PROVIDER: GSE137266 | GEO | 2019/09/12

REPOSITORIES: GEO

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