Gene expression data of organoids derived from traditional serrated adenomas

ABSTRACT: Traditional serrated adenomas (TSAs) are rare colorectal polyps characterized by unique histology features. Fusions in R-spondin genes have been found in TSAs, but it is not clear whether these are sufficient for TSA development. We established 2 patient-derived TSA organoid lines, and engineered chromosome rearrangements that involve R-spondin genes into human colonic organoids using CRISPR-Cas9. Consequently, we highlighted the similarity of the gene expression patterns between TSA organoids and engineered organoids.

ORGANISM(S): Homo sapiens

PROVIDER: GSE137336 | GEO | 2019/10/23

REPOSITORIES: GEO