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Stem cell derived human microglia transplanted in mouse brain to study human disease

ABSTRACT: While genetics highlight the role of microglia in Alzheimer’s disease (AD), one third of putative AD-risk genes lack adequate mouse orthologs. Here, we successfully engraft human microglia derived from embryonic stem cells in the mouse brain. The cells recapitulate transcriptionally human primary microglia ex vivo and show expression of human specific AD-risk genes. Oligomeric Amyloid-β induces a divergent response in human vs. mouse microglia. This model can be used to study the role of microglia in neurological diseases.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE137444 | GEO | 2019/10/16

REPOSITORIES: GEO

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