Transcriptomics

Dataset Information

0

The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia


ABSTRACT: In this work we dissect the functional role of the HOXB-AS3 long non coding RNA in patients with NPM1-mutated (NPM1mut) acute myeloid leukemia (AML). We show that HOXB-AS3 regulates the proliferative capacity of NPM1mut AML blasts in vitro and in vivo. HOXB-AS3 was found to interact with the ErbB3-binding protein 1 (EBP1) and guide EBP1 to the ribosomal DNA locus. Via this mechanism HOXB-AS3 regulates ribosomal RNA transcription and de novo protein synthesis. We propose that in the context of NPM1 mutations, HOXB-AS3 overexpression acts as a compensatory mechanism, which allows adequate protein production in leukemic blasts.

ORGANISM(S): Homo sapiens

PROVIDER: GSE137851 | GEO | 2019/10/15

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2019-10-16 | PXD015520 | Pride
2019-07-16 | GSE114823 | GEO
| PRJNA472769 | ENA
| PRJNA573666 | ENA
2014-05-01 | E-GEOD-55519 | biostudies-arrayexpress
2014-05-01 | GSE55519 | GEO
2016-08-22 | E-GEOD-85107 | biostudies-arrayexpress
2021-03-09 | GSE168444 | GEO
2016-08-22 | GSE85107 | GEO
2019-05-14 | GSE128603 | GEO