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NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_2

ABSTRACT: We report the differential gene expression analysis of DSS treated colon tissues obtained from WT and NAIL-ΔNFκB mouse.

ORGANISM(S): Mus musculus

PROVIDER: GSE138235 | GEO | 2020/11/01

REPOSITORIES: GEO

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NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_1

Project description:We report the genome wide occupancy of p65, H3K4Me3, H3K27Ac and p300 in MCF7-NAIL-WT and MCF7-NAIL-ΔNFκB cells stimulated with TNF alpha for 0min, 45min and 90 min.

2023-09-01 | GSE138308 | GEO

NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-11-02 | GSE138310 | GEO

NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_4

Project description:We report the differential gene expression analysis of lncRNAs in wild-type, p65 KO and IKK2 KO MEFs stimulated with TNF alpha for 0min, 45min and 90 min.

2020-11-01 | GSE157476 | GEO

NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_3

Project description:We report the differential gene expression analysis in MCF7-NAILWT and MCF7-NAILΔNFκB cells stimulated with TNF alpha for 0min, 45min and 90 min.

2023-09-01 | GSE138237 | GEO

NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation

Project description:NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation

| PRJNA575378 | ENA

NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_4

Project description:NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_4

| PRJNA661450 | ENA

NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_1

Project description:NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_1

| PRJNA575382 | ENA

NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_2

Project description:NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_2

| PRJNA575183 | ENA

NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_3

Project description:NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_3

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<i>NAIL</i>: an evolutionarily conserved lncRNA essential for licensing coordinated activation of p38 and NFκB in colitis.

Project description:ObjectiveNFκB is the key modulator in inflammatory disorders. However, the key regulators that activate, fine-tune or shut off NFκB activity in inflammatory conditions are poorly understood. In this study, we aim to investigate the roles that NFκB-specific long non-coding RNAs (lncRNAs) play in regulating inflammatory networks.DesignUsing the first genetic-screen to identify NFκB-specific lncRNAs, we performed RNA-seq from the p65-/- and Ikkβ -/- mouse embryonic fibroblasts and report the identification of an evolutionary conserved lncRNA designated mNAIL (mice) or hNAIL (human). hNAIL is upregulated in human inflammatory disorders, including UC. We generated mNAILΔNFκB mice, wherein deletion of two NFκB sites in the proximal promoter of mNAIL abolishes its induction, to study its function in colitis.ResultsNAIL regulates inflammation via sequestering and inactivating Wip1, a known negative regulator of proinflammatory p38 kinase and NFκB subunit p65. Wip1 inactivation leads to coordinated activation of p38 and covalent modifications of NFκB, essential for its genome-wide occupancy on specific targets. NAIL enables an orchestrated response for p38 and NFκB coactivation that leads to differentiation of precursor cells into immature myeloid cells in bone marrow, recruitment of macrophages to inflamed area and expression of inflammatory genes in colitis.ConclusionNAIL directly regulates initiation and progression of colitis and its expression is highly correlated with NFκB activity which makes it a perfect candidate to serve as a biomarker and a therapeutic target for IBD and other inflammation-associated diseases.

| S-EPMC8458091 | biostudies-literature

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