Transcriptomics

Dataset Information

0

Changes in calcium homeostasis and gene expression implicated in epilepsy in hippocampi of mice overexpressing ORAI1


ABSTRACT: We showed that the overexpression of ORAI1 in the neurons of murine brain leads to spontaneous occurrence of seizure-like events in aged animals. We aimed to identify the mechanism responsible for this phenomenon. Using modified Ca2+-addback assay in the slices of CA1 hippocampal region and FURA-2AM calcium indicator we found that overexpression of ORAI1 in neurons leads to altered Ca2+ response. Next, by RNASeq we identified set of genes, whose expression was changed in FVB/NJ-Tg(ORAI1)Ibd mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE138370 | GEO | 2019/12/17

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-12-27 | GSE236706 | GEO
2024-03-13 | GSE244524 | GEO
| S-EPMC6888010 | biostudies-literature
2023-09-21 | E-MTAB-10955 | biostudies-arrayexpress
| PRJNA575645 | ENA
2016-01-14 | GSE76804 | GEO
2016-01-14 | E-GEOD-76804 | biostudies-arrayexpress
2021-04-01 | GSE168349 | GEO
| PRJNA1008414 | ENA
2023-04-01 | GSE213875 | GEO