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Hepatic BCL6 and plasma triglycerides regulate sexual dimorphism in tissue tolerance [set 3]

ABSTRACT: Here, we investigated the role of BCL6 in hepatic response to E.Coli infection. Bcl6 F/F and Bcl6 F/F, Alb-Cre male and female mice were infected with E.Coli and livers were collected 24h after infection for RNAseq analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE138392 | GEO | 2022/10/21

REPOSITORIES: GEO

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Hepatic BCL6 and plasma triglycerides regulate sexual dimorphism in tissue tolerance [set 5]

Project description:Tissue tolerance is a sexually dimorphic trait. Here, we investigated the role of BCL6 in establishing hepatic chromatin landscape promoting sexually dimorphic tissue tolerance during E.Coli infection.

2022-10-21 | GSE138395 | GEO

Hepatic BCL6 and plasma triglycerides regulate sexual dimorphism in tissue tolerance [set 2]

Project description:Hepatic gene expression shows sexual dimorphism. Here, we investigated the role of BCL6 in establishing sexual dimorphism in hepatic gene expression and created Bcl6Flox/Flox,Alb-Cre mice and performed RNAseq from livers of 4- and 8-week-old male and female Ctrl and BCL6 liver knock-out mice.

2022-10-21 | GSE138391 | GEO

Hepatic BCL6 and plasma triglycerides regulate sexual dimorphism in tissue tolerance [set 4]

Project description:Hepatic gene expression shows sexual dimorphism. Here, we investigated the role of BCL6 in establishing sexually dimorphic chromatin state and performed H3K27ac ChIP-seq from livers of female and male Ctrl and BCL6 liver knock-out mice.

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Hepatic BCL6 and plasma triglycerides regulate sexual dimorphism in tissue tolerance [set 2]

Project description:Hepatic BCL6 and plasma triglycerides regulate sexual dimorphism in tissue tolerance [set 2]

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Hepatic BCL6 and plasma triglycerides regulate sexual dimorphism in tissue tolerance [set 5]

Project description:Hepatic BCL6 and plasma triglycerides regulate sexual dimorphism in tissue tolerance [set 5]

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Hepatic BCL6 and plasma triglycerides regulate sexual dimorphism in tissue tolerance [set 4]

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Hepatic BCL6 and plasma triglycerides regulate sexual dimorphism in tissue tolerance [set 3]

Project description:Hepatic BCL6 and plasma triglycerides regulate sexual dimorphism in tissue tolerance [set 3]

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Hepatic BCL6 and plasma trigylecrides regulate sexual dimorphism in tissue tolerance [set6_GDX]

Project description:Hepatic BCL6 and plasma trigylecrides regulate sexual dimorphism in tissue tolerance [set6_GDX]

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Hepatic BCL6 and plasma trigylecrides regulate sexual dimorphism in tissue tolerance [set6_GDX]

Project description:Aim of the experiment was to study the role of gonadectomy and testosterone treatment on liver gene expression of male mice. Gonadectomized male mice received infusion of testosterone or vehicle, and liver was used to perform RNAseq analysis.

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Small molecule-induced polymerization triggers degradation of BCL6

Project description:Most small-molecule protein degraders act as interface stabilizers ‘molecular glues’ between E3 ubiquitin ligases and target proteins to induce ternary complex formation and ubiquitin-dependent target protein degradation. Here we report polymerization as a novel mechanism for small molecule-induced degradation. Using functional screens in combination with molecular and biochemical assays, we found that BI-3802, which binds to the BTB domain of the oncogenic transcription factor BCL6, induces polymerization of BCL6 into regular helical structures in vitro and foci in vivo. Polymerization precedes degradation by the SIAH1 E3 ubiquitin ligase. Hereby, a VxP amino acid motif on BCL6, distal from the drug-binding BTB domain, is required for SIAH1 binding, ubiquitination and BI-3802-induced degradation. Our findings propose that small molecule-induced polymerization is not only a new modality for targeted protein degradation, but also provides synthetic biology with a tool for tunable protein polymerization and opens new avenues for future drug design.

2020-11-20 | PXD016185 | Pride

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