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RNA-sequencing in Mouse Embryonic Fibroblasts exposed to different Intensities of Hyperosmotic Stress

ABSTRACT: The inability of cells to adapt to increased environmental tonicity can lead to inflammatory gene expression and pathogenesis. The Rel family of transcription factors TonEBP and NF-κB p65 play critical roles in the switch from osmoadaptive homeostasis to inflammation, respectively. Here we identified a marker of the termination of adaptation and initiation of inflammation. We found that high stress inhibits protein interactions essential for the increased expression of TonEBP-dependent osmoprotective genes. This resulted in enhanced formation of TonEBP/NF-κB p65 complexes and enhanced proinflammatory gene expression.

ORGANISM(S): Mus musculus

PROVIDER: GSE138692 | GEO | 2019/10/11

REPOSITORIES: GEO

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