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RNA sequencing of whole Dorsal Root Ganglia (DRG) upon Environmental Enrichment and Sciatic Nerve Axotomy (EE_SNA) or Sciatic Nerve Axotomy alone (SH_SNA) compared to Standard Housing Sham (SH_Sham)

ABSTRACT: Purpose: compare the gene expression in whole DRG of mice: A) undergone to nerve axotomy vs control condition B) pre-exposed to EE and undergone to nerve axotomy vs control condition Results: we found that EE_SNA induces transcriptional changes strongly promoting axon regeneration. We call this "Enriched Conditioning"

ORGANISM(S): Mus musculus

PROVIDER: GSE138769 | GEO | 2020/10/12

REPOSITORIES: GEO

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Proximal sciatic nerve stumps exhibit sexually dimorphic transcriptome changes in mice after peripheral nerve injury (axotomy)

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Project description:RNA sequencing of whole Dorsal Root Ganglia (DRG) upon Environmental Enrichment and Sciatic Nerve Axotomy (EE_SNA) or Sciatic Nerve Axotomy alone (SH_SNA) compared to Standard Housing Sham (SH_Sham)

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Proximal sciatic nerve stumps exhibit sexually dimorphic transcriptome changes in mice after peripheral nerve injury (axotomy)

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