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RNA sequencing of whole Dorsal Root Ganglia (DRG) upon Environmental Enrichment and Sciatic Nerve Axotomy (EE_SNA) or Sciatic Nerve Axotomy alone (SH_SNA) compared to Standard Housing Sham (SH_Sham)

ABSTRACT: Purpose: compare the gene expression in whole DRG of mice: A) undergone to nerve axotomy vs control condition B) pre-exposed to EE and undergone to nerve axotomy vs control condition Results: we found that EE_SNA induces transcriptional changes strongly promoting axon regeneration. We call this "Enriched Conditioning"

ORGANISM(S): Mus musculus

PROVIDER: GSE138769 | GEO | 2020/10/12

REPOSITORIES: GEO

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Proximal sciatic nerve stumps exhibit sexually dimorphic transcriptome changes in mice after peripheral nerve injury (axotomy)

Project description:Transcriptional changes are distinct in female and male mice in the time course of peripheral nerve injury response. Here, we present sexually dimorphic transcriptome profiles established in the space of 24 h period after sciatic nerve axotomy.

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MicroRNA profiling in dorsal root ganglion after sciatic nerve injury

Project description:Changes in microRNA (miRNA) expression in the mouse L4 and L5 dorsal root ganglion following unilateral sciatic nerve transection. The timepoint of 7 days post-axotomy was chosen to capture miRNA expression profiles at a time when the injured neurons were beginning to regenerate. Two condition experiment, paired control DRG vs axotomised DRG following unilateral sciatic nerve transection. 3 biological replicates, one replicate per array. Dye swap in Replicate 2.

2011-05-06 | E-GEOD-29096 | biostudies-arrayexpress

RNA sequencing of whole Dorsal Root Ganglia (DRG) upon Environmental Enrichment and Sciatic Nerve Axotomy (EE_SNA) or Sciatic Nerve Axotomy alone (SH_SNA) compared to Standard Housing Sham (SH_Sham)

Project description:RNA sequencing of whole Dorsal Root Ganglia (DRG) upon Environmental Enrichment and Sciatic Nerve Axotomy (EE_SNA) or Sciatic Nerve Axotomy alone (SH_SNA) compared to Standard Housing Sham (SH_Sham)

| PRJNA577104 | ENA

MicroRNA profiling in dorsal root ganglion after sciatic nerve injury

2011-05-06 | GSE29096 | GEO

RNA-Seq of regenerating DRG neurons

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MeDIP-chip from dorsal root ganglia (DRG) tissue from wildtype mice, for 5-methyl-cytosine

Project description:Nerve injury in the peripheral nervous system allows spontaneous regeneration, in contrast to injury of central nerves, which lead to a differential expression pattern of regeneration-associated genes and others. These genes might be regulated by promoter DNA methylation As regeneration model, DRG tissue was analyzed for methyated gene promoters and CpG islands following both injury types. A differential methylation pattern could be identified, although most genes remained unmethylated. comparison of DRG following either sciatic nerve axotomy (SNA) or dorsal column axotomy (DCA) - each 'real injury or sham' - at 1, 3 or 7 days post-injury vs. 'naive', Each sample was pooled from two mice, yielding an immunoprecipitated sample ('Test') and an input genomic DNA sample (Ref). altogether 33 microarrays were used for 13 conditions with triplicate arrays for 'real injury' or 'naive' samples, and duplicate arrays for 'sham' samples.

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In vivo analysis of camptothecin effect in primary DRG neuron after sciatic nerve injury

Project description:Analysis of gene expression in injured primary DRG with or without camptothecin (CPT) treatment after sciatic nerve crushing may help us identify critical molecular pathways related to axon regeneration. We performed RNA-sequencing of (i) Naive primary DRG tissues without injury, (ii) Primary DRG tissues with vehicle treatment different time-points (18, 24, 36 hours) after sciatic nerve injury, and (iii) Primary DRG tissues with camptothecin treatment different time-points (18, 24, 36 hours) after sciatic nerve injury.

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Clathrin IP_mouse sciatic nerve axons_Roylab_UCSD

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Gene expression from aged and young sciatic nerve after nerve injury

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