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Genome-wide map of MAZ transcription factor in primary human erythroid cells

ABSTRACT: We report the distribution of binding sites of Myc-associated zinc finger (MAZ) transcription factor in primary human erythroid cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE139281 | GEO | 2021/06/30

REPOSITORIES: GEO

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MAZ induces MYB expression during the exit from quiescence via the E2F site in the MYB promoter

Project description:Most E2F-binding sites repress transcription through the recruitment of Retinoblasoma (RB) family members until the end of the G1 cell-cycle phase. Although the MYB promoter contains an E2F-binding site, its transcription is activated shortly after the exit from quiescence, before RB family members inactivation, by unknown mechanisms. We had previously uncovered a nuclear factor distinct from E2F, Myb-sp, whose DNA-binding site overlapped the E2F element and had hypothesized that this factor might overcome the transcriptional repression of MYB by E2F-RB family members. We have purified Myb-sp and discovered that Myc-associated zinc finger proteins (MAZ) are major components. We show that various MAZ isoforms are present in Myb-sp and activate transcription via the MYB-E2F element. Moreover, while forced RB or p130 expression repressed the activity of a luciferase reporter driven by the MYB-E2F element, co-expression of MAZ proteins not only reverted repression, but also activated transcription. Finally, we show that MAZ binds the MYB promoter in vivo, that its binding site is critical for MYB transactivation, and that MAZ knockdown inhibits MYB expression during the exit from quiescence. Together, these data indicate that MAZ is essential to bypass MYB promoter repression by RB family members and to induce MYB expression.

2017-10-04 | PXD006857 | Pride

Genome-wide map of MAZ transcription factor in primary human erythroid cells

Project description:Genome-wide map of MAZ transcription factor in primary human erythroid cells

| PRJNA579097 | ENA

Maz

Project description:Rattus norvegicus Maz, MYC associated zinc finger protein [Source:RGD Symbol;Acc:1594632], is expressed in 4 baseline experiment(s);

| ENSRNOG00000055082 | ExpressionAtlas

Maz

Project description:Rattus norvegicus Maz, MYC associated zinc finger protein [Source:RGD Symbol;Acc:1594632], is differentially expressed in 18 experiment(s);

| ENSRNOG00000055082 | ExpressionAtlas

MAZ

Project description:Sus scrofa MAZ, MYC associated zinc finger protein [Source:HGNC Symbol;Acc:HGNC:6914], is expressed in 3 baseline experiment(s);

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maz

Project description:Xenopus tropicalis maz, MYC associated zinc finger protein [Source:Xenbase;Acc:XB-GENE-1021005], is expressed in 1 baseline experiment(s);

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MAZ

Project description:Equus caballus MAZ, MYC associated zinc finger protein [Source:VGNC Symbol;Acc:VGNC:20003], is expressed in 1 baseline experiment(s);

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MAZ

Project description:Homo sapiens MAZ, MYC associated zinc finger protein [Source:HGNC Symbol;Acc:HGNC:6914], is expressed in 52 baseline experiment(s);

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Project description:Sus scrofa MAZ, MYC associated zinc finger protein [Source:HGNC Symbol;Acc:HGNC:6914], is differentially expressed in 1 experiment(s);

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MAZ

Project description:Macaca mulatta MAZ, MYC associated zinc finger protein [Source:HGNC Symbol;Acc:HGNC:6914], is expressed in 3 baseline experiment(s);

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