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Gene expression profiling of dynamic paracrine senescence in human fibroblasts

ABSTRACT: Cellular senescence can be transmitted to neighbouring cells in a paracrine manner through different mechanisms, including soluble factors released by senescent cells. To understand the dynamic regulation of paracrine senescence, here we investigated gene expression profiles in normal human fibroblasts (IMR90) exposed to conditioned medium generated by an inducible model of fibroblast Oncogene-Induced Senescence (IMR90-ER:RAS) at different time points after induction of senescence.

ORGANISM(S): Homo sapiens

PROVIDER: GSE139563 | GEO | 2022/04/05

REPOSITORIES: GEO

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