Transcriptomics

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Characterisation of HIF-dependent alternative isoforms in pancreatic cancer


ABSTRACT: Intra-tumor hypoxia is a common feature in many solid cancers. Although transcriptional targets of hypoxia-inducible factors (HIFs) have been well characterized, alternative splicing or processing of pre-mRNA transcripts which occurs during hypoxia and subsequent HIF stabilization is much less understood. Here, we identify HIF-dependent alternative splicing events after whole transcriptome sequencing in pancreatic cancer cells exposed to hypoxia with and without downregulation of the aryl hydrocarbon receptor nuclear translocator (ARNT), a protein required for HIFs to form a transcriptionally active dimer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE139673 | GEO | 2019/11/01

REPOSITORIES: GEO

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