Transcriptomics

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Comparison of MPA regulated gene expression profiles to those regulated by PROG, DHT, DEX


ABSTRACT: Medroxyprogesterone acetate (MPA) is a progestin that can bind to and activate progesterone, androgen and glucocorticoid receptors. However, it is not known which receptor mediates MPA action in a cellular context where all three of these receptors are co-expressed and functional. This microarray experiment was performed to compare the transcriptomes induced by MPA and the cognate ligands for these receptors ie progesterone (PROG), 5a-dihydrotestosterone (DHT) and dexamethasone (DEX) in breast cancer cells to determine which was most similar to MPA.

ORGANISM(S): Homo sapiens

PROVIDER: GSE139870 | GEO | 2020/01/22

REPOSITORIES: GEO

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