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RNA-seq time course on human CD4 memory T cells stimulated with anti-CD3/CD28 beads

ABSTRACT: In this study we sought to analyze the effects of genetic variants on gene regulation in a cell-state dependent manner during CD4 memory T cell activation. To do this, we performed an RNA-seq time series experiment on CD4 memory T cells activated with anti-CD3/CD28 beads in individuals with no autoimmune disease. We measured gene expression levels, and allele-specific expression at heterozygous sites over time. We found widespread dynamic genetic regulatory effects across the genome, with an enrichment for genes found in autoimmune disease risk loci.

ORGANISM(S): Homo sapiens

PROVIDER: GSE140244 | GEO | 2019/11/13

REPOSITORIES: GEO

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