Transcriptomics

Dataset Information

0

FBXW7 coordinates postprandial muscle glucose metabolism and maintenance of skeletal muscle mass


ABSTRACT: In this study, we show that muscle-specific inactivation of FBXW7 elicits striking defects in postprandial glucose metabolism and failure to maintain skeletal muscle mass in adult mice. Further, mice lacking FBXW7 exhibited impaired endurance capacity and exacerbated HFD-induced insulin resistance and postprandial hyperglycemia. At the mechanistic level, RNAseq and quantitative proteomic analysis revealed global effects of FBXW7 deficiency on skeletal muscle transcriptome and proteome. This work illustrates a prominent role of FBXW7 in integrating postprandial nutritional signals to coordinate glucose metabolism and muscle mass maintenance.

ORGANISM(S): Mus musculus

PROVIDER: GSE140503 | GEO | 2024/06/21

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2012-02-21 | E-GEOD-31901 | biostudies-arrayexpress
2012-02-21 | GSE31901 | GEO
| PRJNA783287 | ENA
| 2256 | ecrin-mdr-crc
2012-02-10 | E-GEOD-35661 | biostudies-arrayexpress
2009-11-16 | E-TABM-213 | biostudies-arrayexpress
2019-08-01 | GSE130839 | GEO
2019-08-01 | GSE130838 | GEO
2022-01-08 | GSE193089 | GEO
2017-04-20 | GSE79925 | GEO