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Tamoxifen induces cleft palate in mice

ABSTRACT: Tamoxifen (TAM), a widely-used drug in treating breast cancer, has been reported to be associated with craniofacial defects including micrognathia and cleft palate in humans. However, the exact effects of TAM on the developing palate remain unclear. In the present study, we conclude that excess TAM exposure causes cleft palate defect in mice by regulating MAPK pathways, which implicates the importance of tightly regulated MAPK signaling in palate development and provides a basis for further exploration of the molecular etiology of cleft palate defects caused by environmental factors.

ORGANISM(S): Mus musculus

PROVIDER: GSE140836 | GEO | 2022/11/22

REPOSITORIES: GEO

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Tamoxifen induces cleft palate in mice

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