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Mouse transcriptome reveals signatures of protection and pathogenesis in human tuberculosis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE140945 | GEO | 2020/01/09

REPOSITORIES: GEO

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Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis.

Project description:Although mouse infection models have been extensively used to study the host response to Mycobacterium tuberculosis, their validity in revealing determinants of human tuberculosis (TB) resistance and disease progression has been heavily debated. Here, we show that the modular transcriptional signature in the blood of susceptible mice infected with a clinical isolate of M. tuberculosis resembles that of active human TB disease, with dominance of a type I interferon response and neutrophil activation and recruitment, together with a loss in B lymphocyte, natural killer and T cell effector responses. In addition, resistant but not susceptible strains of mice show increased lung B cell, natural killer and T cell effector responses in the lung upon infection. Notably, the blood signature of active disease shared by mice and humans is also evident in latent TB progressors before diagnosis, suggesting that these responses both predict and contribute to the pathogenesis of progressive M. tuberculosis infection.

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Mouse transcriptome reveals novel signatures of protection and pathogenesis in human tuberculosis [lung]

Project description:Characterisation of blood and lung global transcriptional responses to Mycobacterium tuberculosis infection in distinct mouse models of Tuberculosis

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Mouse transcriptome reveals novel signatures of protection and pathogenesis in human tuberculosis [blood]

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