Transcriptomics

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RNAseq of 2'3' cGAMP injected Drosophila melanogaster


ABSTRACT: We recently reported that an orthologue of STING regulates infection by picorna-like viruses in drosophila. Here, we show that injection of flies with 2’3’-cGAMP can induce expression of dSTING-regulated genes. Analysis of the transcriptome of 2’3’-cGAMP injected flies reveals a complex pattern of response, with early and late induced genes. Our results reveal that dSTING regulates an NF-κB -dependent antiviral program, which predates the emergence of Interferon Regulatory Factors and interferons in vertebrates.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE140955 | GEO | 2020/05/31

REPOSITORIES: GEO

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