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Biological significance of CDYL in endometrial receptivity

ABSTRACT: Impaired endometrial receptivity is one of the major causes of recurrent implantation failure (RIF), and the underlying molecular mechanism has not been fully elucidated. We demonstrated that Chromodomain Y like (CDYL) was highly expressed in the endometrium at mid-secretory phase during the normal menstrual cycles. However, the expression of CDYL was down-regulated in the endometrial tissues obtained from women with RIF, consistently with the protein level of LIF, which is the marker of endometrial receptivity. Knockdown of CDYL significantly decreased the cell migration of human endometrial Ishikawa cells and primary endometrial cells. Genomic analyses revealed that CDYL gene silencing resulted in decreased expression of many genes associated with cytoskeleton and migration regulation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE141239 | GEO | 2020/09/28

REPOSITORIES: GEO

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Biological significance of CDYL in endometrial receptivity

Project description:Biological significance of CDYL in endometrial receptivity

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