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The hepatic methylome of liver-specific insulin receptor knockout (LIRKO) mouse offspring

ABSTRACT: Liver-specific insulin receptor knockout (LIRKO) mouse is a unique non-dietary model of insulin resistant, hyperglycemia, dyslipidemia and atherosclerosis that resembles several clinical features of the human metabolic syndrome. By enhanced reduced representation bisulfite sequencing (ERRBS) analysis of the livers of wild-type (WT) offspring of LIRKO mice, we identified that genes with differential DNA methylation were enriched for cholesterol synthesis, MAPK, AKT, insulin and TGF-β signaling, including the NREP and GDF15.

ORGANISM(S): Mus musculus

PROVIDER: GSE141379 | GEO | 2021/01/04

REPOSITORIES: GEO

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The hepatic transcriptome of liver-specific insulin receptor knockout (LIRKO) mouse offspring

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