Transcriptomics

Dataset Information

0

Immunological fingerprints of controllers developing neutralizing HIV-1 antibodies


ABSTRACT: Induction of broadly neutralizing antibodies (bnAbs) is highly desired for an effective vaccine against HIV-1. Typically, bnAbs develop in patients with high viremia, but can also evolve in some untreated HIV-1 controllers with low viral loads. Here, we identify a subgroup of neutralizer-controllers characterized by myeloid DC (mDCs) with a distinct inflammatory signature and a superior ability to prime T follicular helper (Tfh)-like cells in an STAT4-dependent fashion. This distinct immune profile is associated with a higher frequency of Tfh-like cells in peripheral blood (pTfh) and an enrichment for Tfh-defining genes in circulating CD4+ T cells. Correspondingly, Monocytes from this neutralizer controller subgroup upregulate genes encoding for chemotaxis and inflammation, and secrete high levels of IL-12 in response to TLR stimulation. Together, our results suggest multi-compartment immune networks between mDCs, Tfh and Monocytes that might facilitate development of bnAbs in a subgroup of HIV-1 controllers.

ORGANISM(S): Homo sapiens

PROVIDER: GSE141498 | GEO | 2020/01/28

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2017-02-01 | GSE90897 | GEO
| PRJNA593611 | ENA
2010-02-02 | GSE20075 | GEO
| PRJEB48153 | ENA
2010-10-08 | E-GEOD-20075 | biostudies-arrayexpress
2023-03-11 | PXD033766 | Pride
2024-07-23 | GSE254781 | GEO
2024-07-23 | GSE254836 | GEO
2021-05-03 | GSE167564 | GEO
2014-08-04 | E-GEOD-58868 | biostudies-arrayexpress