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Microarray comparing CMV-specific CD8+ T cells from liver sinusoid and peripheral blood

ABSTRACT: The liver is an immunologically unique organ in terms of the regulation of immuno-tolerance and immune responses. Recently, non-recirculating tissue-resident memory T (TRM) cells expressing CD69 were found in various peripheral organs. In humans, a large population of CD69+CD8+ memory T cells residing in liver sinusoids shows reduced cytotoxicity. However, the trascriptional characteristics of human liver CD8+ T cells are still unknown. Therefore, we performed a microarray analysis to screen the gene expression profile in liver sinusoidal CD8+ T cells using CMV-specific CD8+ T cells from human peripheral blood and liver sinusoid.

ORGANISM(S): Homo sapiens

PROVIDER: GSE141508 | GEO | 2019/12/06

REPOSITORIES: GEO

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