Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effects of Mucosa associated fungi on IEC

ABSTRACT: RNAseq of intestinal epithelial cells from ASF Mice colonized with a consortium of mucosa associated fungi

ORGANISM(S): Mus musculus

PROVIDER: GSE141622 | GEO | 2021/12/30

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Effects of Mucosa associated fungi on IEC

Project description:Effects of Mucosa associated fungi on IEC

| PRJNA594143 | ENA

Study on the relationship between changes of intestinal fungi and primary liver cancer

Project description:Interventions: Case series:None Primary outcome(s): intestinal fungi Study Design: Sequential

| 35158 | ecrin-mdr-crc

Time course profiling of IEC and total colonic tissue transcriptome in T.mu colonized animals

Project description:In this experiment we profiled the transcriptome of intestinal colonic epithelium and total colonic tissue of animals colonized with T.mu versus naïve littermate controls at different time points

2017-08-07 | GSE86111 | GEO

p38a-dependent gene expression in the colonic mucosa

Project description:Gene expression in the colonic mucosa of wild-type and p38a-knockout intestinal epithelial cells (IECs) were compared. C57BL/6 wild-type mice, and intestinal epithelial cell-specific p38a-knockout mice on a C57BL/6 background were used for isolation of colonic mucosa

2014-07-01 | GSE55356 | GEO

p38a-dependent gene expression in the colonic mucosa

2014-07-01 | E-GEOD-55356 | biostudies-arrayexpress

Quantitative proteomics of intestinal mucosa from male mice lacking intestinal epithelial insulin receptors

Project description:The goal of the present study was to determine whether loss of the insulin receptor alters the molecular landscape of the intestinal mucosa, using intestinal-epithelial insulin receptor knockout (IE-irKO) mice and both genetic (IRfl/fl and Villin-cre) controls. Quantitative proteomic analysis by Liquid Chromatography Mass Spectrometry (LC-MS) was deployed on jejunal and colonic mucosa from mice fed a chow- or Western diet (WD). Jejunal mucosa from IE-irKO mice demonstrated alterations in all intestinal cell linages, Paneth, goblet, absorptive and enteroendocrine cells, whereas only goblet and absorptive cells were affected in the colon. There was also a significant effect of the WD on the gut proteome. A significant reduction was detected in Paneth cell proteins with anti-microbial activity, including lysozyme C-1, angiogenin-4, cryptdin-related sequence1C-3 and -2, a-defensin 17 and intelectin-1a. The key protein expressed by goblet cells, mucin-2, was also reduced in the IE-irKO mice. Proteins involved in lipid metabolism, including aldose reductase-related protein 1, 15-hydroxyprostaglandin dehydrogenase [NAD(+)], apolipoprotein A-II and pyruvate dehydrogenase kinase isozyme 4, were increased in the mucosa of WD-fed IE-irKO mice as compared to controls. In contrast, expression of the nutrient-responsive gut hormones, glucose-dependent insulinotropic polypeptide and neurotensin, was reduced in the jejunal mucosa of IE-irKO mice, and there was a reduction in proteins of the P-type ATPases and the solute carrier-transporter family in the colon of WD-fed IE-irKO mice. In conclusion, IE-irKO mice display a distinct molecular phenotype, suggesting a biological role of insulin and its receptor in determining differentiated cell-specificity in the intestinal epithelium.

2017-08-18 | PXD005932 | Pride

pig intestinal mucosa-associated microbiota

Project description:pig intestinal mucosa-associated microbiota Metagenome

| PRJNA524979 | ENA

scATAC-seq analysis using gastric mucosa with intestinal metaplasia

Project description:Nucleosome positionings of gastric mucosa with intestinal metaplasia at single cell resolution

2023-10-01 | GSE221292 | GEO

Expression data from intestinal mucosa of Zucker rats

Project description:Obesity is a chronic, complex and multifactorial disease that has reached pandemia levels and is becoming a serious health problem. Intestinal microbiota is considered a main factor that affects body weight and fat mass, which points toward a critical role in the development of obesity. In this sense, probiotic bacteria might modulate the intestinal microbiota and the mucosal-associated lymphoid tissue. The aim of this study was to investigate the effects of L. paracasei, L. rhamnosus and B. breve feeding on the intestinal mucosa gene expression in a genetic animal model of obesity. We used microarrays to investigate the global gene expression on intestinal mucosa after the treatment with probiotic strains.

2016-12-25 | GSE73848 | GEO

ChIP-seq analysis of H3K27acethylation using gastric mucosa with intestinal metaplasia

Project description:Histone modification of H3K27acethylation in gastric mucosa with intestinal metaplasia

2023-10-01 | GSE220681 | GEO