Characterization of growth-phase dependent expression of host factors that modulate mutagenic retrohoming in Legionella pneumophila through RNA-Seq analysis

ABSTRACT: Diversity-generating retroelements (DGRs) function through a mutagenic retrohoming mechanism that introduces localized nucleotide substitutions in genes. Throught transcriptional profiling of the DGR genes and host global regulatory networks, here we probe how tight host-control over DGR activity balances the benefit of localized protein diversification with the potential loss of fitness from unbridled mutagenesis.

ORGANISM(S): Legionella pneumophila

PROVIDER: GSE141830 | GEO | 2020/12/25

REPOSITORIES: GEO