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Immunotherapy against amyloid beta is modulated by meningeal lymphatic function I

ABSTRACT: A growing body of evidence points to passive immunotherapy as a promising therapeutic strategy against AD. Herein, we show that meningeal lymphatic vasculature becomes dysfunctional in AD transgenic mice and that manipulating meningeal lymphatic drainage affects the outcome of anti-Aβ immunotherapy.

ORGANISM(S): Mus musculus

PROVIDER: GSE141849 | GEO | 2021/03/11

REPOSITORIES: GEO

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Immunotherapy against amyloid beta is modulated by meningeal lymphatic function III

Project description:A growing body of evidence points to passive immunotherapy as a promising therapeutic strategy against AD. Herein, we show that meningeal lymphatic vasculature becomes dysfunctional in AD transgenic mice and that manipulating meningeal lymphatic drainage affects the outcome of anti-Aβ immunotherapy.

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Immunotherapy against amyloid beta is modulated by meningeal lymphatic function

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