Transcriptomics

Dataset Information

0

Single cell RNA sequencing of Hic1 and PDGFRa-labeled cells in the heart


ABSTRACT: The cardiac stroma contains multipotent mesenchymal progenitors. However, lineage relationships within cardiac stromal cells are poorly defined. Here, we identify heart-resident PDGFRa+ SCA-1+ cells as cardiac Fibro/Adipogenic Progenitors (cFAPs) and show that they respond to ischemic damage by generating SCA-1- fibrogenic cells. Pharmacological blockade of this differentiation step with an anti-fibrotic tyrosine kinase inhibitor decreases post-myocardial infarction (MI) remodeling and leads to improvement in heart function.

ORGANISM(S): Mus musculus

PROVIDER: GSE141928 | GEO | 2020/01/23

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-01-23 | GSE141927 | GEO
| PRJNA595180 | ENA
| PRJNA595321 | ENA
2019-12-12 | GSE141866 | GEO
2019-12-12 | GSE141844 | GEO
2019-03-28 | E-MTAB-7365 | biostudies-arrayexpress
2013-08-01 | E-GEOD-39361 | biostudies-arrayexpress
2022-07-27 | GSE166854 | GEO
2018-09-03 | GSE118555 | GEO
2013-08-01 | GSE39361 | GEO