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Expansion of polyfuntional CD57+ KLRG1+ senescent CD4+ and CD8+ T cells in breast cancer patients.

ABSTRACT: We used microarrays to compare the gene expression profile of DP and DN (KLRG1 and CD57) CD4+ T cells from luminal breast cancer patients and healthy donors.

ORGANISM(S): Homo sapiens

PROVIDER: GSE142080 | GEO | 2021/08/18

REPOSITORIES: GEO

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Expansion of polyfuntional CD57+ KLRG1+ senescent CD4+ and CD8+ T cells in breast cancer patients.

Project description:Expansion of polyfuntional CD57+ KLRG1+ senescent CD4+ and CD8+ T cells in breast cancer patients.

| PRJNA595881 | ENA

Transcription profiling of CD8+CD57+ T cells from healthy donors and HIV patients

Project description:Gene Array Analysis of CD8+ CD57+ T cells in HIV Patients. Gene expression patterns of CD8+CD57+ T cells from healthy donors and HIV patients were compared. Gene expression patterns of CD8+CD57- T cells and CD8+CD57+ T cells were compared.

2005-07-30 | E-MEXP-393 | biostudies-arrayexpress

RNA-sequencing of three murine memory CD8 T cell subsets: IL-7Rα+KLRG1- , IL-7Rα+KLRG1+, and IL-7Rα-KLRG1+

Project description:The goal of this study is to characterize the transcriptional profile of three memory CD8 T cell subsets: IL-7Rα+KLRG1- (memory precursors, MP), IL-7Rα+KLRG1+ (KLRG1+ MP) and IL-7Rα-KLRG1+ (terminal effectors, TE).

2022-12-12 | GSE218777 | GEO

Characterization of CD57+PD1- CD4 T cells

2016-01-08 | GSE64805 | GEO

Characterization of CD57+PD1- CD4 T cells

Project description:We have identified a CD57+PD1- CD4 T cell phenotype at the time of transplantation that strongly correlates with subsequesnt development of belatacept-resistant rejection. In this study, we used microarray to determine which genes were upregulated in CD57+ compared to CD57- CD4 T cells. Peripheral blood obtained from 5 healthy controls was processed and sorted into CD4+CD57+PD1- and CD4+CD57-PD1- populations. Total RNA was extracted from the sorted populations and quality assessed. cDNA synthesis and amplification was performed, and fragmented and biotinylated samples were hybridized to the Affymetrix Human U133 plus 2.0 probe array. The arrays were scanned and probe intensity measurements were normalized across the samples using the robust multichip average (RMA) algorithm.

2016-01-08 | E-GEOD-64805 | biostudies-arrayexpress

Transcriptional profiling of CD45RO+CD57+CD4+ T cells

Project description:RNA-seq data to examine transcriptiome of CD57+ versus CD57- memory CD4+ T cells

2019-07-20 | GSE134536 | GEO

Single-cell RNA-sequencing of blood and tonsillar CD4+ CD57+ and CD57- T cells

Project description:Gene-environment interactions are implicated in immunopathology, but few specific mechanisms have been identified. We defined two terminal-differentiation pathways for human CD4+ T cells each marked by CD57. Rare blood CD57+ CD4+ T cells marked by TCF1 downregulation (Thcyt) adopt a cytotoxic and terminal-effector transcriptome. By contrast, human CD57+ GC-Tfh cells exhibit a transcriptome of the precursor exhausted T cells marked by TCF7, TOX and ID3 and constitutive expression of CTLA4, which collectively confer resistance to becoming cytotoxic. By clarifying human CD4+ T cell terminal differentiation, we have revealed how CTLA4 mitigates the risk of maladaptive cytotoxicity during infection.

2023-04-27 | GSE200257 | GEO

RNA sequencing of CD57+ and CD57- effector memory CD8 T cells in patients with type 1 diabetes

Project description:Type 1 diabetes is an autoimmune disease in which insulin-secreting β cells of the pancreatic islets are selectively destroyed. CD8 T cells are regarded as critical players in mediating β cell destruction and as a result, considerable effort has been expended to define CD8 T cell behaviour in this disease. The overarching aim of the experiment is to characterize a recently identified autoreactive CD57-positive CD8 T cell subset which is associated with loss of function of islet beta cells in type 1 diabetes, to compare the phenotype of the CD57-positive effector memory CD8 T cells versus the CD57-negative compartment, and provide an insight into the function of these cells in the disease process. To that aim, HLA-A*24 positive patients with T1D -within 2 years of diagnosis- were asked to provide a blood, and following consent, and PBMC were isolated. CD57-positive and CD57-negative CD8 T cell populations were sorted by FACS, and finally, RNA was extracted. Amplified cDNA was obtained and used for the library preparation.

2018-08-03 | E-MTAB-6727 | biostudies-arrayexpress

Reduced Ebola vaccine responses in CMV+ young adults is associated with expansion of CD57+KLRG1+ T cells.

Project description:CMV is associated with immunosenescence and reduced vaccine responses in the elderly (>70 yr). However, the impact of CMV in young adults is less clear. In this study, healthy UK and Senegalese adults aged 18-50 yr (average, 29 yr) were vaccinated with the Ebola vaccine candidate chimpanzee adenovirus type 3-vectored Ebola Zaire vaccine (ChAd3-EBO-Z) and boosted with modified vaccinia Ankara Ebola Zaire-vectored (MVA-EBO-Z) vaccine. CMV carriage was associated with an expansion of phenotypically senescent CD4+ and CD8+ T cells expressing CD57 and killer cell lectin-like receptor G1 (KLRG1), which was negatively associated with vaccine responses in both cohorts. Ebola-specific T cell responses induced by vaccination also contained significantly increased frequencies of terminally differentiated CD57+KLRG1+ cells in CMV seropositive (CMV+) individuals. This study suggests that CMV can also affect vaccine responses in younger adults and may have a particularly marked impact in many developing countries where CMV seroprevalence is almost universal.

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Comparison of Expression profile between CD3-CD56dimCD16+ CD57+ and CD57neg NK cells

Project description:Thirty to 60% of CD56dimCD16bright NK cells in healthy adults express CD57, which is not expressed on immature CD56bright NK cells or fetal and newborn NK cells. We hypothesized that CD57+ NK cells within the CD56dim mature NK cell subset are highly mature and might be terminally differentiated. We used microarrays to assess the transcriptional differences between CD57+ and CD57neg NK cells within the CD56dim mature NK subset.

2010-08-18 | GSE23695 | GEO

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